GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs2294008 | 1 | rs2572910 | chr8:143770135 | LY6D | chr8:143866298-143868008:- | 0.23 | 4.83 | 1.95E-6 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| BLCA | cis | rs2294008 | 1 | rs2572910 | chr8:143770135 | PSCA | chr8:143761875-143764142:+ | 0.52 | 16.12 | 5.65E-45 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| BLCA | cis | rs2762051 | 1 | rs2580191 | chr13:50809938 | CAB39L | chr13:49882787-50018221:- | 0.23 | 4.36 | 1.64E-5 | Celiac disease |
| BLCA | cis | rs2581794 | 1 | rs2581794 | chr3:53036206 | SFMBT1 | chr3:52938628-53080070:- | 0.23 | 3.85 | 0.000136 | Schizophrenia |
| BLCA | cis | rs2294008 | 1 | rs2585179 | chr8:143774193 | LY6D | chr8:143866298-143868008:- | 0.23 | 4.84 | 1.86E-6 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| BLCA | cis | rs2294008 | 1 | rs2585179 | chr8:143774193 | PSCA | chr8:143761875-143764142:+ | 0.52 | 16.21 | 2.37E-45 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| BLCA | cis | rs732528 | 1 | rs2586759 | chr18:48379064 | MRO | chr18:48321491-48351754:- | -0.25 | -4.48 | 9.97E-6 | Entorhinal cortical thickness |
| BLCA | cis | rs732528 | 1 | rs2586761 | chr18:48366458 | MRO | chr18:48321491-48351754:- | -0.25 | -4.58 | 6.16E-6 | Entorhinal cortical thickness |
| BLCA | cis | rs732528 | 1 | rs2586762 | chr18:48367625 | MRO | chr18:48321491-48351754:- | -0.26 | -4.75 | 2.93E-6 | Entorhinal cortical thickness |
| BLCA | cis | rs732528 | 1 | rs2586765 | chr18:48369584 | MRO | chr18:48321491-48351754:- | -0.26 | -4.74 | 3.0E-6 | Entorhinal cortical thickness |
| BLCA | cis | rs261360 | 1 | rs261360 | chr20:5037774 | C20orf30 | chr20:5049130-5093733:- | -0.25 | -4.16 | 3.88E-5 | Hair morphology |
| BLCA | cis | rs2251844 | 1 | rs2614811 | chr15:43913487 | ADAL | chr15:43622872-43646094:+ | -0.4 | -4.47 | 1.04E-5 | Tumor biomarkers |
| BLCA | cis | rs2251844 | 1 | rs2614811 | chr15:43913487 | CATSPER2 | chr15:43922774-43959900:- | -0.36 | -5.16 | 3.94E-7 | Tumor biomarkers |
| BLCA | cis | rs9815354 | 1 | rs2625667 | chr3:41900951 | ULK4 | chr3:41288091-42003660:- | 0.64 | 9.91 | 9.53E-21 | Diastolic blood pressure |
| BLCA | cis | rs9815354 | 1 | rs2625668 | chr3:41905930 | ULK4 | chr3:41288091-42003660:- | 0.64 | 9.91 | 9.53E-21 | Diastolic blood pressure |